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Scientist warns of a new covid variant with a large number of mutations

a new version of COVID-19 More than 30 spike mutations have been reported from southern Africa. On 23 November Dr. Tom Peacock, a virologist at Imperial College London, Version details are posted on github.com, noting that “the incredibly high amount of spike mutations suggest it may be of real concern (predicted to escape most known monoclonal antibodies)”

Specified as b.1.1.529, the variant was first observed in Botswana and the other circulating countries are Hong Kong and South Africa. According to Guardian, only 10 cases have been confirmed by genomic sequencing.

Dr Tom Peacock tweeted that the version should be monitored due to its “terrible spike profile”.

According to the WHO, at present, there are only four types of coronavirus The forms of concern are designated as – alpha (lineage b.1.1.7, so-called ‘UK version’), beta (lineage b.1.351, so-called ‘South Africa version’), gamma (lineage p.1, so-called ‘Brazil’) var’) and delta (lineage b.1.617.2).

“It’s worth emphasizing right now that there are super low numbers in an area of ​​Africa that is fairly well sampled, however, because of that terrible spike profile it needs to be monitored a lot (guess it would be about even more than the antigen) Worse would be about something else),” said Dr. Peacock.

The mutation P681H observed in the new variant has also been reported in the alpha, Mu, some gamma and B.1.1.318 variants. The new variant also contains the N679K mutation that has been reported in several other variants. Dr. Peacock tweeted: “This is the first time I’ve seen two of these mutations in the same variant”

The new variant also carries a mutation called N501Y that has been reported in other forms of anxiety. Studies have shown that this mutation helps to make the variant more passable. This allows the virus to readily bind to human angiotensin-converting enzyme 2 (ACE2) receptors.

It also carries the P681H mutation, one of the commonly identified spike mutations in SARS CoV-2, which increases the transmissibility of the virus. The D614G mutation, which has been reported to increase the infectivity of the virus, was also observed in the new variant.

Dr. Divya Tej Soupathi, CSIR-Centre for Cellular and Molecular Biology said that very few genomic sequences of the new variants are available and more studies are needed. “The version is currently being monitored,” he says.

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